Shiga Toxin E. coli Study in East Lansing

E. coli outbreak researchers at Michigan State University will study strategies to reduce the amount of E. coli released by cattle under a $2.5 million grant from the U.S. Department of Agriculture. The hope is that a reduction in E. coli O157:H7 will correspond with a decrease in the number of foodborne illnesses in humans.

The intestines of cattle are the primary reservoir for E. coli O157:H7 bacteria and other types of E. coli that emit powerful Shiga toxin once ingested by humans. The animals shed the bacteria in feces and it can contaminate butchered meat and many other foods depending on circumstances. Michigan State said in a press release that molecular biologist and epidemiologist Shannon Manning will lead the multi-disciplinary shedding study.

Part of the research goal is to better understand shedding of E. coli from Michigan cattle and dairy cows with the goal of enhancing detection methods and control strategies. Maybe there are farming practices that could reduce colonization of the microbes inside the animals. The research team expects to develop new ideas for direct-fed antimicrobials, vaccines, therapies and other control strategies that can reduce the frequency and level of Shiga toxin E. coli shedding.   

The grant was awarded through USDA's National Institute of Food and Agriculture. The agency supports research that promotes and enhances the scientific discipline of food safety. 
 
Hemolytic uremic syndrome (HUS) is a life-threatening condition caused by E. coli O157:H7 in 5 to 15 percent of case patients. It is one of the most dangerous results of food poisoning. The condition can develop in any person of any age, but children under 5 are most susceptible and they almost always suffer kidney failure. HUS E. coli also can cascade into a multitude of other health problems, including anemia, stroke, inflamation of the brain, heart problems and central nervous system disorders, including paralysis. 
 
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